Vinyl Chloride Exposure Liver

Portal hypertension liver fibrosis and angiosarcoma of the liver asl have been reported among workers exposed to vinyl chloride monomer vcm since the 1970s.

Vinyl chloride exposure liver.

In the very first study about the dangers of vinyl chloride published by patty in 1930 it was disclosed that exposure of test animals to just a single short term high dose of vinyl chloride caused liver damage. Occupational safety health administration provides information about exposure limits to vinyl chloride. This substance has been found in at least 616 of the 1 662 national priority list sites identified by the environmental protection agency epa. The causal link between vinyl chloride exposure and lung cancer must be further investigated.

Shipped as a liquefied compressed gas. In 1949 a russian publication discussed the finding that vinyl chloride caused liver injury among workers. The evidence of a causal link between vinyl chloride exposure and liver cancer is anyhow confirmed. Bofetta p matisane l mundt ka dell ld.

However the data on which this conclusion is based is incomplete. Angiosarcoma and hepatocellular carcinoma. Meta analysis of studies of occupational exposure to vinyl chloride in relation to cancer mortality. Breathing vinyl chloride for long periods of time can result in permanent liver damage immune reactions nerve damage and liver cancer.

It also has other toxic effects on the liver and it has recently been suggested that exposure to vinyl chloride also causes hepatocellular carcinoma. 1 3 butadiene ethylene oxide and vinyl halides vinyl fluoride vinyl chloride and vinyl bromide. Liver side effects of vinyl chloride. Vinyl chloride is also known to cause fibrosis scarring of the liver which is a risk factor for hepatocellular carcinoma.

The liver converts a small amount of vinyl chloride into an even more powerful toxin that stays in the body and causes health problems like angiosarcoma an aggressive type of liver cancer that starts inside blood vessels. Vinyl chloride exposure is associated with an increased risk of a rare form of liver cancer hepatic angiosarcoma as well as brain and lung cancers lymphoma and leukemia. There is inadequate ascertainment of unequivocal diagnoses. How can exposures be reduced.

The evidence for a carcinogenic risk has been extended to jobs associated with poly vinyl chloride exposure. Chloroethene chloroethylene ethylene monochloride monochloroethene monochloroethylene vc vcm vinyl chloride monomer vcm colorless gas or liquid below 7 f with a pleasant odor at high concentrations. Vinyl chloride monomer is a known cause of angiosarcoma of the liver. Liver damage is the most serious health risk of vinyl chloride.